Angewandte Chemie (International ed. in English)
Iizuchalasin A: A Marine Fungal Metabolite With a Cage-Like Structure That Binds TarG to Inhibit Wall Teichoic Acid Biosynthesis by Multidrug-Resistant S. aureus.
Rui Zhang, Huanqin Dai, Baosong Chen, Haifeng Wang, Yuxi Qin, Jinwei Ren, Ming Zhang, Ruopeng Yin, Jingzu Sun, Junjie Han, Yaojun Tong, Yonghui Zhang, Hongwei Liu
Published: 202610.1002/anie.202523303
Abstract
To address the ongoing Staphylococcus aureus drug resistance, we screened marine fungal extracts against a multidrug-resistant strain and performed a metabolome analysis to identified new antibiotics with larger molecular size. Targeted isolation yie…
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