Angewandte Chemie (International ed. in English)
Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship.
Marloes A M Pennings, Merel A W van den Bosch, Ansgar Oberheide, Carlo J A Verhoef, Christian Ottmann, Albert J Markvoort, Galen P Miley, Luc Brunsveld
Published: 202510.1002/anie.202521678
Abstract
Molecular glues (MGs) stabilize protein-protein interactions (PPIs) by simultaneously binding two or more proteins at their composite interface. Macrocycles present attractive properties as MGs, including large contact surfaces to address the often f…
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