Angewandte Chemie (International ed. in English)Cytochrome P-450 Enzyme SystemOxidation-ReductionTriterpenesAntrodiaLanosterol
A Unique CYP450 Enzyme Unlocks Antrodia Camphorata Lanostane Triterpenoid Diversity Through Oxidation and Skeletal Rearrangement.
Shungang Jiao, Wentao Sun, Youcai Hu
Published: 202610.1002/anie.202521539
Abstract
Lanostane triterpenoids, key therapeutic components of medicinal mushrooms, such as rare Antrodia camphorata, face heterologous biosynthesis barriers due to the lack of enzymes for essential C21/C15 oxidation and skeletal rearrangement, limiting acce…
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