Angewandte Chemie (International ed. in English)
Copper-Catalyzed Enantioselective Radical Desymmetrizing Cyclization of Cyclopentenes: Access to Chiral 2-Azabicyclo[2.2.1]Heptan-3-ones.
Jing Zhong, Mengxian Li, Jiao Ma, Zimo Zhang, Hao Fang, Shang Gao, Aijun Lin, Hequan Yao
Published: 202610.1002/anie.202521476
Abstract
We herein report an unprecedented copper-catalyzed enantioselective radical desymmetrizing cyclization of cyclopentenes through peroxidation-amination and alkylamination. This strategy provides a general and efficient route for the synthesis of chira…
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