Angewandte Chemie (International ed. in English)
A Multimodal Ensemble Framework for Optimal Mutant Prediction and Computational Enzyme Engineering.
Ding Luo, Huining Ji, Baodong Hu, Jinxing Cai, Kaiqi Wen, Xiaoyang Qu, Mingfeng Cao, Xinrui Zhao, Binju Wang
Published: 202510.1002/anie.202521396
Abstract
Exploring mutational landscape of proteins to engineer improved enzymes remains a fundamental challenge. Traditional methods, whether reliant on high-throughput experimentation, direct evolution, or on computational prediction, often face challenges…
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