Angewandte Chemie (International ed. in English)
A Convergent Hybrid Gram-Scale Synthesis of Tirzepatide: Tangential Flow Filtration Assisted Native Chemical Ligation-Desulfurization Approach.
Ankur Jalan, Emily S Murzinski, Patrick J Jansen, Richard D Miller, Matthew C Embry, Roger B Scherer, John F Moomaw, Katerina M Williams, Cyrus A Fisher, Jinju James, Christine A Arbour, Emily J Guinn, Jing Teng, Michael E Kopach
Published: 202510.1002/anie.202520060
Abstract
The development of scalable and efficient manufacturing of high-volume complex synthetic peptides and proteins, like tirzepatide (TZP, 1), faces major hurdles due to the limitations of traditional Solid Phase Peptide Synthesis (SPPS) and Liquid Phase…
Preview only. Read the full abstract at the source