Angewandte Chemie (International ed. in English)
Stereodivergent Construction of Spiropyrrolidine-γ-Butyrolactones Enabled by Cu/Ru Sequential Catalysis and Stereoselective Reduction.
Qi Xiong, Kui Tian, Xin-Lian Liu, Ling He, Yao-Wen Song, Yi Liu, Zuo-Fei Wang, Xiu-Qin Dong, Chun-Jiang Wang
Published: 202610.1002/anie.202519537
Abstract
The stereodivergent synthesis of spiroheterocycles bearing multiple stereocenters is a pivotal yet challenging frontier in asymmetric catalysis, particularly for rigid scaffolds integrating pharmacophoric pyrrolidine and γ-butyrolactone motifs with s…
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