Angewandte Chemie (International ed. in English)
Iridium Porphyrin-Catalyzed Asymmetric Rearrangement of Oxindoles with Aryl Diazoesters: Enantioselective Synthesis of Chiral Tertiary 2-Indolyl Alcohols.
Ya-Zhou Lin, Shanshan Yuan, Yu Xu, Heng-Yu Hu, Xiao-Ming Zhao, Yi-Guo Liang, Sheng-Cai Zheng
Published: 202610.1002/anie.202519102
Abstract
The asymmetric functionalization of indoles at the C2 position to afford chiral tertiary alcohols poses a formidable challenge in organic synthesis, primarily due to the inherent preference for C3 reactivity. Herein, we report the asymmetric generati…
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