Angewandte Chemie (International ed. in English)HumansZincAntineoplastic AgentsPeptidesAnimals
PSMA-Triggered Phase Separation of Peptide-Drug Conjugates Enables Zinc-Dependent Tumor Inhibition.
Kai Han, Jian Zhang, Xiaolu Miao, Yao Yu, Limin Zhang, Jinge Zhao, Xin Wang, Qinsong Wei, Yongming Li, Yubin Ke, Bing Ma, Weizhi Wang
Published: 202610.1002/anie.202518980
Abstract
Peptide-drug conjugates (PDC) have emerged as a promising modality for targeted tumor therapy, offering high specificity, and design flexibility. However, the therapeutic efficacy of PDC is often limited by rapid systemic clearance, inadequate contro…
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