Angewandte Chemie (International ed. in English)
Enantioselective Synthesis of Inherently Chiral Calix[4]arenes via Catalytic Asymmetric Lower-Rim Functionalization.
Lei Peng, Yu Chang, Shujun Tong, Wenling Qin, Gianpiero Cera, Hailong Yan
Published: 202510.1002/anie.202518659
Abstract
We report herein an efficient approach for the enantioselective synthesis of inherently chiral calix[4]arenes (ICCs) via chiral phosphoric acid (CPA)-catalyzed lower-rim asymmetric functionalization. With vinylidene ortho-quinone methides (VQMs) as t…
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