Angewandte Chemie (International ed. in English)alpha-SynucleinHumansCalmodulinIon Mobility SpectrometryMass Spectrometry
Time-Resolved In-Cell Protein Interactions and Structural Dynamics via Rapid Buffer Online Exchange-Ion Mobility-Mass Spectrometry.
Jun Liu, Xiaoli Wang, Xiangjun Si, Rui Zhao, Weida Qin, Gongyu Li
Published: 202610.1002/anie.202518076
Abstract
Observing protein structural dynamics directly within the complex cellular milieu is crucial for understanding biology but is hampered by severe matrix interference in mass spectrometry. Here, we introduce the RapiBOX-IM-MS platform, which enables ti…
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