Angewandte Chemie (International ed. in English)CysteineSulfhydryl CompoundsProteinsHumans
A Picolyl-Based Cys Caging/Uncaging Strategy Facilitates Protein Synthesis.
Farong Ye, Hanxi Bai, Xinliang Liu, Peng Xu, Guoping Ding, Ping Huang, Xiaheng Zhang, Biao Yu, Ping Wang
Published: 202510.1002/anie.202518002
Abstract
Endowed with a reactive thiol group, cysteine (Cys) provides a versatile handle for site-specific bioconjugation and serves as a cornerstone of chemical protein synthesis, particularly in native chemical ligation (NCL). Extensions such as expressed p…
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