Atroposelective Synthesis of Ultrarigid Chiral Styrenes via Pd-Catalyzed Unconventional 5-exo-dig Cyclization/Carbonylation of 1,5-Enynes.

Axially chiral styrenes represent a promising class of atropisomers with broad potential in asymmetric catalysis, drug discovery, and materials science. However, their catalytic asymmetric synthesis remains underdeveloped due to the conformational fl…

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