Angewandte Chemie (International ed. in English)
Site-Selective Ligand Selection by Mutational Profiling for Covalent RNA Targeting.
Phillip Yesley, Georgia Poulladofonou, Danny Incarnato, Willem A Velema
Published: 202510.1002/anie.202517243
Abstract
To facilitate the design of RNA-targeted covalent probes we report a bottom-up, structure-informed approach using mutational profiling. We designed a compact library of covalent probes based on the scaffold of Ribocil, a selective inhibitor targeting…
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