Angewandte Chemie (International ed. in English)
Photocatalytic Radical Umpolung for Strain-Release Difunctionalization of (Aza)bicyclo[1.1.0]butanes.
Chang-Yin Tan, Hyewon Ju, Jinwook Jeong, Jaehun Kim, Sungwoo Hong
Published: 202510.1002/anie.202517231
Abstract
Azetidines and cyclobutanes are increasingly valued as potent bioisosteres of pyridines and benzenes in medicinal chemistry. Herein, we report a radical umpolung strategy for the regioselective difunctionalization of azabicyclo[1.1.0]butanes (ABBs) a…
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