Angewandte Chemie (International ed. in English)
Coumarin-30 Enables Site-Resolved Detection of Tubulin Ligands by Microscale Thermophoresis.
Mikhail N Anisimov, Maksim A Boichenko, Anton A Sivachev, Alexey N Romanov, Ilya A Lifshits, Julia N Borzunova, Marina Janibekova, Vadim V Mustyatsa, Timur P Tikhonov, Andrey Yu Plodukhin, Vitaly V Shorokhov, Victor A Tafeenko, Nina K Ratmanova, Sergey S Zhokhov, Roman A Novikov
Published: 202510.1002/anie.202517086
Abstract
Tubulins are among the most successful targets for cancer chemotherapy. However, the emergence of drug resistance stimulates the continuous search for novel chemotherapeutics. We discovered that coumarin-30, a widely available laser dye, binds to the…
Preview only. Read the full abstract at the source