Angewandte Chemie (International ed. in English)
Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W Andy Tao, Emily C Dykhuizen, Casey J Krusemark
Published: 202610.1002/anie.202516630
Abstract
Targeted covalent inhibitors (TCIs) are increasingly popular as drug candidates and chemical probes. Among current TCIs, the chemistry is largely limited to cysteine and lysine side chain reactivity. Here, we investigated the utility of cyclic imine…
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