Angewandte Chemie (International ed. in English)Campylobacter jejuniSugar AcidsProtein Engineering
Rational Engineering of a Pseudaminic Acid Synthase Enzyme Enables Access to a 3-Fluoro Sugar with Motility Inhibition in Bacterial Pathogens.
James M Jeffries, Abigail J Walklett, Natasha E Hatton, Bartosz Kowalski, Tessa Keenan, Lickson Munjoma, Richard Haigh, Christopher D Bayliss, Gavin H Thomas, Martin A Fascione
Published: 202510.1002/anie.202515851
Abstract
We report the rational engineering of a pseudaminic acid synthase (PseI), which enables the first synthesis of a 3-fluorinated pseudaminic acid sugar (3-(eq)-F-Pse5Ac7Ac), potentially establishing a new class of metabolic inhibitors targeting bacteri…
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