Phosphine-Catalyzed Enantioselective [2 + 2] Annulations of α-Allyl γ-Benzyl Allenoates via a Transannular Cyclization Approach.

Fused cyclobutane frameworks are valuable scaffolds in natural products and pharmaceuticals, yet catalytic asymmetric methods for their construction remain rare due to ring strain and stereocontrol challenges. Here, we report a spiro phosphine-cataly…

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