Angewandte Chemie (International ed. in English)G-QuadruplexesHumansUbiquitin-Protein LigasesProteolysisDEAD-box RNA Helicases
Degradation of G-Quadruplex-Binding Proteins by G4L-PROTAC via Quaternary Complex Formation.
Rena Nohara, Yuma Tanaya, Mohammad Jafar Sheikhi, Pratiksha Chaudhary, Grinsun Sharma, Hanbin Mao, Kazuo Nagasawa, Masayuki Tera
Published: 202510.1002/anie.202515045
Abstract
G-Quadruplexes (G4s) are noncanonical nucleic acid secondary structures enriched in genomic regions critical for transcription and replication. These dynamic scaffolds recruit G4-binding proteins (G4BPs), thereby regulating diverse cellular processes…
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