Angewandte Chemie (International ed. in English)AptamersNucleotideKineticsThermodynamicsDNA
Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand-Displacement Reaction.
Yuzhe Ding, Yicheng Heng, Ka-Ying Wong, Qingyu Chen, Juewen Liu
Published: 202610.1002/anie.202514445
Abstract
Selection of high affinity aptamers is the basis for aptamer-related applications. Most aptamer selections prioritize thermodynamic factors such as the target concentration but neglect interaction kinetics. Using ampicillin as a target, aptamer selec…
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