Angewandte Chemie (International ed. in English)HumansCell-Penetrating PeptidesProlineHydrophobic and Hydrophilic InteractionsClick Chemistry
Click-Cyclized Cell Penetrating Peptides Containing Hydrophobic Proline Derivatives for Efficient Intracellular Delivery.
Yuan Zhang, Jacob Kæstel-Hansen, David Teze, Ge Huang, Sanne Schoffelen, Michael Lisby, Min Zhang, Nikos S Hatzakis, Morten Meldal
Published: 202510.1002/anie.202504862
Abstract
Targeting intracellular organelles with macromolecules is challenging due to cell membrane impermeability. Innovative approaches to direct intracellular delivery have been developed, including nanoparticles, as a promising method for protein delivery…
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