Annals of neurology
Confined B-Cell Reconstruction and High T-Cell Clonality Define Clinical Response to Cladribine Treatment.
Tilman Schneider-Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M Schumann, Jan D Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab
Published: 202610.1002/ana.78165
Abstract
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B- and T-cell r…
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