Annals of neurology
Additive Effects of White Matter Hyperintensity and APOE ε4 Status on Risk of Incident Dementia in Two Large Longitudinal Cohorts.
Adam de Havenon, Lauren Littig, Santiago Clocchiatti-Tuozzo, Ian P Johnson, Sofia Constantinescu, Cyprien A Rivier, Shufan Huo, William T Kimberly, Teresa Gomez-Isla, Yvonne Kim, Eric Stulberg, Eric E Smith, Jonathan Rosand, Guido Falcone, Kevin N Sheth
Published: 202510.1002/ana.78103
Abstract
OBJECTIVE: To evaluate whether white matter hyperintensities (WMH) and apolipoprotein E (APOE) ε4 status have an additive or multiplicative effect on the risk of incident all-cause dementia. METHODS: We conducted a prospective cohort study in the Ath…
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