Animal models and experimental medicine
Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis.
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou
Published: 202610.1002/ame2.70101
Abstract
BACKGROUND: Skeletal tuberculosis (TB) remains a persistent clinical and research challenge due to its chronic course, osteolytic destruction, and the limitations of existing animal models, which often require high-level biosafety containment or fail…
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