International forum of allergy & rhinology
Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells.
Joel C Thompson, April Park, Yobouet Ines Kouakou, Zoey A Miller, Nabil F Darwich, Nithin D Adappa, James N Palmer, Ryan M Carey, Robert J Lee
Published: 202510.1002/alr.70084
Abstract
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis-related chronic rhinosinusitis (CF-CRS) that produces phenazine metabolites pyocyanin and 1-hydroxyphenazine (1-HP), which may have detrimental effects on mitochondria…
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