Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Enantioselective Reductive Alkenylation of α-CF2H (-CF3) Amino Halides: Rapid Access to Chiral α-CF2H (-CF3) Allylamines.
Peng Liu, Kuiliang Li, Yan He, Chen-Hui Jiang, Ruo-Xing Jin, Duo-Duo Hu, Wei-Cheng Zhao, Xuan Nie, Shang-Zheng Sun, Xi-Sheng Wang
Published: 202610.1002/advs.73986
Abstract
The incorporation of fluoroalkyl groups into drug candidates has garnered increasing attention in the pharmaceutical industry due to their ability to modulate lipophilicity, permeability, metabolic stability, and binding affinity. Despite significant…
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