Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Engineered Bacteria-Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity.
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang
Published: 202610.1002/advs.202524303
Abstract
Radiotherapy (RT) remains a cornerstone in cancer treatment, yet its efficacy is often compromised by tumor-acquired radioresistance, driven in part by lactate accumulation in the tumor microenvironment (TME). Lactate fosters therapeutic resistance t…
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