Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ROS-Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF-κB-LCN2 Inflammatory Feedback Loop.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei
Published: 202610.1002/advs.202521709
Abstract
Intervertebral disc degeneration (IVDD) is driven by persistent inflammation-oxidative stress that disrupts annulus fibrosus (AF) homeostasis. Guided by network pharmacology and docking, we prioritized the NF-κB-LCN2 axis as a druggable target of wed…
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