Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Bioorthogonal Sonodynamic Plug-and-Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng
Published: 202510.1002/advs.202520975
Abstract
Targeted protein degradation (TPD) offers powerful therapeutic opportunities but is limited by poor tissue penetration and E3 ligase dependence. Herein, we develop Sonodynamic Plug-and-Play Targeting Chimeras (SDPTAC), an ultrasound (US)-activated, b…
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