Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A Biomimetic Norepinephrine-Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical-Sized Bone Defects.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo
Published: 202510.1002/advs.202518807
Abstract
Effective regeneration of critical-sized bone defects requires integrated coordination among osteogenesis, neurogenesis, angiogenesis, and immune modulation-yet most biomaterials fail to address these dimensions simultaneously. Here, a norepinephrine…
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