Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells.
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang
Published: 202610.1002/advs.202517895
Abstract
Alternative splicing is a fundamental mechanism that enhances proteomic diversity and modulates gene function, with its dysregulation being a hallmark of numerous diseases. Despite its biological significance, the real-time monitoring of spliced mRNA…
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