Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery.
Wenhan Wang, Kangfu Chen, Zongjie Wang
Published: 202510.1002/advs.202517617
Abstract
Lipid nanoparticles (LNPs) are useful carriers for therapeutic siRNA delivery, yet their clinical efficacy remains constrained by insufficient cellular uptake. Here, using a genome-wide CRISPR knockout screen, multiple genetic modulators of LNP uptak…
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