Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A Reactive Antagonist Strategy: Cysteine-Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation.
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka
Published: 202610.1002/advs.202517463
Abstract
Controlling protein-protein interactions (PPIs) remains a challenge in modern chemistry. In plants, jasmonoyl-L-isoleucine (JA-Ile) acts as a molecular glue that facilitates PPIs between the F-box protein COI1 and JAZ repressors, leading to transcrip…
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