Advanced science (Weinheim, Baden-Wurttemberg, Germany)
GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer.
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K Barlow, Joel R Steele, Emma Salisbury, Daniel Croagh, Kathryn S Stok, Anna V Taubenberger, Ralf B Schittenhelm, Daniela Loessner
Published: 202610.1002/advs.202516578
Abstract
Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor microenvironment (TME). Inhibiting glutamic-oxaloacetic transaminase 1 (GOT1) is a strategy to target glutamine metabolism and impair cance…
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