Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Genome-Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross-Protection.
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen
Published: 202510.1002/advs.202516448
Abstract
Live attenuated influenza vaccines (LAIVs) can elicit broad immunity, but rational attenuation strategies are limited. PR8rp, a prototype influenza A virus with five segments extensively reprogrammed to use the least-preferred synonymous codons is ge…
Preview only. Read the full abstract at the source