Advanced science (Weinheim, Baden-Wurttemberg, Germany)
IL-4/STAT6-signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis.
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker Bm, Weiss Fu, Sendler M, Glaubitz J
Published: 202610.1002/advs.202515585
Abstract
In both acute and chronic pancreatitis, the local pancreatic immune response has a significant influence on the course of the disease. Utilizing a murine model deficient in STAT6, we demonstrate that the IL-4/IL-13/STAT6-signaling pathway, which is a…
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