Advanced science (Weinheim, Baden-Wurttemberg, Germany)
The Pivotal Role of GR-CAR Pathway in Fetal Programming of Hepatic Cytochrome P450 3A Alteration in Adulthood.
Xiaoxiang Sun, Jie Liu, E Xiang, Xia Li, Xuerong Yan, Yuxi Wang, Feng Li, Hao Kou, Hui Wang, Yu Guo
Published: 202510.1002/advs.202515583
Abstract
Multiple prenatal adverse environmental factors alter hepatic cytochrome P450 (CYP) enzymes expression in offspring, with these changes persisting after birth. These factors induce fetal exposure to excessive maternal glucocorticoids (GCs), however,…
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