Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A Closed-Loop-Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non-Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording.
Chao-Yi Chu, Zih-Huei Chen, Chun-Wei Liang, Pu-Wei Wu, Wei-Qing Guo, Bo-Wei Chen, Chih-Chia Huang, Ssu-Ju Li, Ching-Wen Chang, Yao-Wen Liang, Shun-An Kan, Yu-Chun Lo, Wei-Chen Huang, You-Yin Chen, San-Yuan Chen
Published: 202510.1002/advs.202515060
Abstract
Closed-loop neuromodulation requires precise, stable, and cell-specific control of neural circuits with minimal invasiveness. However, conventional optogenetic systems are hindered by invasive optical fibers, viral-based gene delivery, and disjointed…
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