Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A-IGF2BP1 for Ischemic Stroke Rescue.
Ling Li, Yong-Dong Guo, Xiao-Wen Zhang, Zhi-Yong Du, Yu-Qi Wang, Zhuo Yang, Qian-Wei Luo, Fang-Fang Zhuo, Tian-Tian Wei, Zheng-Ping Liu, Bo Han, Wei Yu, Pei-Pei Zhang, Wei Zhou, Zhi-Yuan Lu
Published: 202510.1002/advs.202514703
Abstract
Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) mediates stress granules (SGs) via phase separation. However, there is limited understanding of the allosteric mechanism and the identification of regulatory molecules. Here, we ident…
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