Advanced science (Weinheim, Baden-Wurttemberg, Germany)
WDR5-H3K4me3 Epigenetic Axis Promotes TRMT6-Dependent tRNA M1A Modification to Facilitate Triple-Negative Breast Cancer Progression by Suppressing Ferroptosis.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li
Published: 202510.1002/advs.202513277
Abstract
N1-methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TR…
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