Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Targeting the Notch1-YY1-ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T-Cell-Driven Cancer Cell Pyroptosis.
Ke Zhu, Fa-Peng Zhang, Chao Qin, Zhi-Xiao Song, Cai-Ni Yang, Shu-Sheng Lin, Xian-Huan Yu, Wen-Rui Wu, Chao-Qun Liu, Chao Liu, Lei-Bo Xu
Published: 202510.1002/advs.202512845
Abstract
Immunotherapy has shown a modest clinical benefit in advanced hepatocellular carcinoma (HCC), probably due to tumor immunosuppressive functions. Although Notch1 signaling has been implicated in tumor immune escape, its underlying mechanism is unclear…
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