Advanced science (Weinheim, Baden-Wurttemberg, Germany)
CD27 and ICOS as Targets of PD-1/PD-L1 Signaling to Regulate Resident Memory CD8+ T-Cell-Mediated Pulmonary Protection and Pathology.
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao
Published: 202510.1002/advs.202512452
Abstract
Tissue-resident memory CD8+ T cells (TRM cells) provide superior frontline defense against pathogens. While the role of costimulation in effector and memory CD8+ T-cell development is well characterized, how costimulatory signaling governs CD8+ TRM c…
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