Advanced science (Weinheim, Baden-Wurttemberg, Germany)
FSTL1 Orchestrates Metabolic-Epigenetic Crosstalk: Glycolysis-Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang Liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang
Published: 202510.1002/advs.202512002
Abstract
The progression of osteoarthritis (OA) is fundamentally characterized by the aberrant transformation of chondrocytes into a fibrotic phenotype, although the precise molecular mechanisms involved remain inadequately understood. In this study, the inte…
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