Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.
Shinya Yokomizo, Megi Maci, April M Stafford, Morgan R Miller, Stephen J Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown-Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L Gillani, Theodore J Zwang, Douglas Richardson, Janice R Naegele
Published: 202510.1002/advs.202511472
Abstract
In addition to dementia, Alzheimer's patients suffer from sleep impairments and aberrations in sleep-dependent brain rhythms. Deficits in inhibitory GABAergic interneuron function disrupt one of those rhythms, slow oscillation in particular, and acti…
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