Advanced science (Weinheim, Baden-Wurttemberg, Germany)
NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1.
Zhen-Xian Niou, Sen Yang, Andrea Enriquez, Nino A Espinas, Anoosha Sri, Caliel D Hines, Jason M Tennessen, Chia-Shan Wu, Jui-Yen Huang, Hui-Chen Lu
Published: 202510.1002/advs.202509950
Abstract
NAD⁺ homeostasis is vital for neuronal health, as demonstrated by the opposing roles of nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), a NAD⁺-synthesizing enzyme, and sterile alpha and TIR motif-containing protein 1 (SARM1), a NAD⁺ hydro…
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