Advanced science (Weinheim, Baden-Wurttemberg, Germany)
TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration.
Maria G Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F Winklhofer
Published: 202510.1002/advs.202509927
Abstract
Optineurin is an autophagy receptor that plays an important role in the selective degradation of mitochondria, protein aggregates, and intracellular pathogens. It recognizes ubiquitylated cargo by its ubiquitin-binding in ABIN and NEMO (UBAN) domain…
Preview only. Read the full abstract at the source