Advanced science (Weinheim, Baden-Wurttemberg, Germany)
5-Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang
Published: 202510.1002/advs.202509682
Abstract
Somatic cell nuclear transfer (SCNT) embryos exhibit widespread epigenetic defects, particularly aberrant DNA methylation. DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation reprogramming during early embryonic development, yet its role in…
Preview only. Read the full abstract at the source