Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J Kittel, Alexander Gottschalk, Adam Claridge-Chang, Shiqiang Gao
Published: 202510.1002/advs.202509180
Abstract
Effective optogenetic inhibition of neuronal activity requires tools that reliably silence neurons across cell types and conditions. K+-selective channelrhodopsins (KCRs) have emerged as attractive alternatives to chloride-conducting channels for opt…
Preview only. Read the full abstract at the source