Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai
Published: 202510.1002/advs.202509151
Abstract
Totipotency represents the greatest potential to yield an entire individual alongside its associated extraembryonic tissues, albeit transiently. Nevertheless, achieving sustainable totipotent stem cells remains an intriguing yet challenging endeavor.…
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